apollo

Select Address

0
  • Login

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM

About

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM belongs to the class of medicine called bacterial enzymes. It is used in the treatment of Dupuytren’s contracture (an abnormal tightening of tissues beneath the skin of the hand) with a palpable cord and Peyronie’s disease (a scar formation under the skin of the penis causing painful erections).

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM contains Collagenase Clostridium histolyticum as an active ingredient, which belongs to the class of bacterial enzymes. It works by hydrolyzing the collagen, thus resulting in the lysis of collagen fragments. 

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM may cause certain common side effects such as confusion, penile rupture, penile pain, tendon rupture, tenderness, and pain at the site of injection. Most of these side effects do not require medical attention. However, you are advised to talk to your doctor if you experience these side effects persistently. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM will be administered by a trained healthcare professional.

Inform your doctor if you are allergic to COLLAGENASE CLOSTRIDIUM HISTOLYTICUM. It is contraindicated in patients with a history of Peyronie’s plaques that involve the penile urethra and severe hypersensitivity reactions. Hence, inform your doctor if you have conditions like liver/kidney disease, bleeding disorders, gastrointestinal disease, and bone disease. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is not recommended for children younger than 18 years of age. Let your doctor know if you are pregnant, planning pregnancy, or breastfeeding.

Uses of COLLAGENASE CLOSTRIDIUM HISTOLYTICUM

Treatment of Dupuytren's contracture with a palpable cord and Peyronie's disease

Medicinal Benefits

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is a bacterial enzyme that helps treat penile fibrosis and Dupuytren’s contracture. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM contains Collagenase Clostridium histolyticum, which works by hydrolysing the collagen under physiological conditions and results in the lysis of collagen fragments. This causes enzymatic disruption of the cord or the plaque.

Directions for Use

A trained healthcare professional will administer COLLAGENASE CLOSTRIDIUM HISTOLYTICUM in the hospital setting. Hence, avoid self-administration. The dose of the medicine will be decided by the doctor based on the type of condition.

Storage

Store in a cool and dry place away from sunlight

Side Effects of COLLAGENASE CLOSTRIDIUM HISTOLYTICUM

  • Confusion
  • Penile pain
  • Penile rupture
  • Tenderness
  • Injection site haematuria
  • Pain at the site of injection
  • Allergic reactions
  • Tendon rupture

In-Depth Precautions and Warning

Drug Warnings

Discontinue taking COLLAGENASE CLOSTRIDIUM HISTOLYTICUM and inform your doctor if you have any allergic reactions. This medicine is contraindicated in patients with a history of Peyronie’s plaques that involve the penile urethra and severe hypersensitivity reactions. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM may cause tendon rupture, ligament damage, or skin laceration if injected into tendons, nerves, blood vessels, or other collagen-containing structures of the hand. It also causes corporal rupture or other serious injuries to the penis, severe hypersensitivity reactions and bleeding disorders. Hence, inform your doctor if you have conditions like liver/kidney disease, abnormal bleeding disorders, and bone disease. Let your doctor know if you are pregnant, planning to be pregnant, or breastfeeding. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is not recommended for children below 18 years of age as the safety and efficacy are not established.

Drug Interactions

Drug-Drug Interactions: COLLAGENASE CLOSTRIDIUM HISTOLYTICUM may interact with anticoagulants (warfarin, heparin, aspirin, clopidogrel) and other medicines

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Inform your doctor if you have any history of liver/kidney disease, bone disorder, or abnormal bleeding condition before receiving COLLAGENASE CLOSTRIDIUM HISTOLYTICUM.

Drug-Drug Interactions Checker List:

  • WARFARIN
  • ASPIRIN
  • HEPARIN
  • CLOPIDOGREL
  • Safety Advice

    • Safety Warning

      Alcohol

      consult your doctor

      It is unknown whether COLLAGENASE CLOSTRIDIUM HISTOLYTICUM interacts with alcohol. Please consult your doctor.

    • Safety Warning

      Pregnancy

      caution

      Limited data available on the effect of COLLAGENASE CLOSTRIDIUM HISTOLYTICUM in pregnancy. Hence, if you are pregnant, or planning pregnancy, inform your doctor before receiving COLLAGENASE CLOSTRIDIUM HISTOLYTICUM. Your doctor may prescribe this medicine if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      If you are breastfeeding, inform your doctor before receiving COLLAGENASE CLOSTRIDIUM HISTOLYTICUM. Your doctor may prescribe this medicine if the benefits outweigh the risks.

    • Safety Warning

      Driving

      safe

      Usually COLLAGENASE CLOSTRIDIUM HISTOLYTICUM does not impact on your ability to drive or operate machinery.

    • Safety Warning

      Liver

      caution

      COLLAGENASE CLOSTRIDIUM HISTOLYTICUM to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      COLLAGENASE CLOSTRIDIUM HISTOLYTICUM to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Children

      unsafe

      COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is not recommended for children under 18 years of age as the safety and effectiveness have not been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Maintaining a healthy weight, eating a balanced diet, and regular exercise may help you manage erectile dysfunction.
    • Avoid consumption of alcohol, as it may temporarily impair your ability to get an erection.
    • Avoid the usage of tobacco.
    • Share intimate time with your partner.

    Patients Concern

    Disease/Condition Glossary

    Dupuytren’s contracture: Also called palmar fibromatosis, is a condition causing an abnormal thickening or tightening of tissues beneath the skin of the hand. This causes curling (contraction) of one or more fingers. It pulls towards your palm and may form a scar over time. The main cause of this condition is unknown but is more common in people with the same family history. It mostly occurs in men than in women.

    Peyronie’s disease: Also called penile fibrosis, is a non-cancerous condition that forms a scar-like tissue called plaque under the skin of the penis. This causes curved and painful erections. It mainly occurs due to repeated penile injury, mostly during sex or physical activity.

    FAQs

    COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is used to treat Dupuytren’s contracture with a palpable cord and Peyronie’s disease.

    COLLAGENASE CLOSTRIDIUM HISTOLYTICUM works by hydrolysing the collagen, thus resulting in the lysis of collagen fragments.

    No, it is not recommended for use of COLLAGENASE CLOSTRIDIUM HISTOLYTICUM in patients with history of bleeding disorder due to serious adverse reactions.

    Taking COLLAGENASE CLOSTRIDIUM HISTOLYTICUM with blood thinners like warfarin may increase the risk of bleeding. Talk to your doctor if you are on blood thinner medications.

    Available Medicines for

    COLLAGENASE CLOSTRIDIUM HISTOLYTICUM

    VIEW MORE PRODUCTS